2019 CSCE Annual Conference - Laval (Greater Montreal)

2019 CSCE Annual Conference - Laval (Greater Montreal) Conference


Title
OCCURRENCE OF IBUPROFEN AND 2-HYDROXY IBUPROFEN IN SAINT LAWRENCE RIVER

Return to Session

Author(s)
Mr. Pourya Zojaji, Concordia University (Presenter)
Mr. Hassan Alhachami
Mr. Esmaeel Kariminezhad, Concordia University
Dr. Shameem Jauffur, Envirogenique
Mrs. Zeinab Bakhshi, Envirogenique
Mr. Marc-Antoine Vaudreuil, University of Montreal
Dr. Sebastien Sauve
Dr. Maria Elektorowicz, Concordia University
Abstract

The widespread occurrence of pharmaceuticals at the minute concentrations in surface waters has revealed emerging anthropogenic effects on the aquatic environment. In this work, to determine the exposure of the Saint Lawrence River to the Ibuprofen (analgesic and anti-inflammatory pharmaceutical product) and its respective 2-hydroxylated metabolite, a municipal wastewater treatment plant (WWTP) and its vicinity were monitored in three locations. Composite samples were taken on an hourly basis, filtered and homogenized in-situ. Automated solid-phase extraction coupled to liquid chromatography tandem mass spectrometry (on-line SPE LC-MS/MS) system was utilized to measure the concentration of selected compounds. The results revealed both compounds were present at the 100% frequency in the Saint Lawrence River. Ibuprofen (IBU) and 2-hydroxy ibuprofen (2-OH IBU) were measured at the concentrations ranging 3.64- 4.40 ng/l and 330-713 ng/l, respectively. Interestingly, the metabolite compound was present at significant higher magnitudes than the parent compound in all sampling sites alongside the river. Concentrations of 2-hydroxy ibuprofen were more remarkable in the downstream of the WWTP outfall where the metabolite level was measured 160-fold higher than the IBU. The results indicated special attention needs to be paid not only to the occurrence of the pharmaceutical active compounds but also their respective stable metabolites in the Saint Lawrence River. Such a conclusion is important considering this riverine ecosystem serves as a food and water source for the millions of people